Susceptibility of Cardiorespiratory Responses to Ozone During Cycling Exercise

University of British Columbia

Status: Enrolling

Conditions: Ozone Exposure During Rest and Exercise

Treatments: Behavioral: Exercise; Other: Room air; Other: Ozone

Study type: Interventional

Funder types: Other

Identifiers

NCT05473000

H22-01389

Details and patient eligibility

About

Ground level ozone (O3) is a common airborne pollutant that is well recognized to cause negative respiratory symptoms and impair pulmonary function. The proposed study aims to have participants perform submaximal and maximal cycling exercise protocols exposed to both O3 and room air in a crossover design to evaluate how ventilatory patterns, pulmonary function, development of symptoms, and cycling performance are impacted by O3 exposure. Additionally, the investigators look to compare responses between O3 at rest and during exercise to predict which subjects may be most susceptible to adverse response, as considerable interindividual variability exists.

Enrollment: 15 estimated patients

Sex: Male

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy males between the age of 18 and 50
• Currently training and/or competing in endurance sport
• VO2max >60 ml/kg/min
• Able to communicate sufficiently using the English language

Exclusion criteria

• History of smoking
• Upper respiratory tract infection within the last 4 weeks
• Presence of any chronic respiratory disease

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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15 participants in 2 patient groups

Ozone (O3)

Experimental group

Description:

Participants of the experimental group will perform sub-maximal exercise (power output associated with 10% below anaerobic threshold for 30 minutes) and maximal exercise (time-to-exhaustion test at 5% above previously determined maximal power output) on a cycle ergometer while inhaling 170ppb ozone delivered continuously during each exercise session.

Treatment:

Other: Ozone

Behavioral: Exercise

Room air

Sham Comparator group

Description:

Participants of the sham group will perform sub-maximal exercise (power output associated with 10% below anaerobic threshold for 30 minutes) and maximal exercise (time-to-exhaustion test at 5% above previously determined maximal power output) on a cycle ergometer while inhaling room air during each exercise session.

Treatment:

Other: Room air

Behavioral: Exercise