Susceptibility to High Altitude Pulmonary Edema in Subjects With Increased Hypoxic Pulmonary Vasoconstriction

Heidelberg University

Status: Completed

Conditions: High Altitude Pulmonary Edema

Treatments: Other: Altitude Exposure:

Study type: Interventional

Funder types: Other

Identifiers

NCT00559442

S-169/2007

Details and patient eligibility

About

It has been shown, that subjects susceptible to high altitude pulmonary edema (HAPE)are characterized by an abnormal increase of pulmonary artery pressure at rest in hypoxia and during exercise in normoxia. This abnormal rise of pulmonary artery pressure has also been observed in about 10 % of otherwise healthy subjects without prior altitude exposure. The aim of the study is to investigate the susceptibility to HAPE in unacclimatized subjects with abnormal increase of pulmonary artery pressure at rest in hypoxia and during exercise in normoxia after rapid ascent to high altitude (4559 m).

Enrollment: 30 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• abnormal increase of pulmonary artery pressure at rest in hypoxia and during exercise in normoxia
• ability to climb Margherita Hut

Exclusion criteria

• Birth at or above 1500 m altitude
• any cardiovascular or pulmonary disease
• Infection disease
• Intake of drugs, in particular Acetazolamide, Nifedipine, corticosteroids or PDE-5-inhibitors.
• Pregnancy

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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30 participants in 1 patient group

1

Experimental group

Description:

high altitude exposure without prior acclimatization

Treatment:

Other: Altitude Exposure: