Suspension of Mechanical Ventilation in Ureteroscopic Lithotripsy Under General Anesthesia

Chinese Medical Association

Status: Unknown

Conditions: Hypercapnia; Hypoxia

Treatments: Other: PEEP

Study type: Interventional

Funder types: NETWORK

Identifiers

NCT01835600

SMV-312

Details and patient eligibility

About

For some upper ureteral and renal stones,ureteroscopic lithotripsy needs to be performed under general anesthesia with interrupted suspension of mechanical ventilation, which could result in hypercapnia and hypoxia. In this study, the investigators hypothesize that 10 cmH2O PEEP added to the respiratory circuit with 1 L/min 100% oxygen might extend the time of ventilation suspension but have no effect on carbon dioxide retention in blood.

Full description

For some upper ureteral and renal stones,ureteroscopic lithotripsy is often perdurbed by the patient's respiratory movement either under epidural anesthesia or general anesthesia with mechanical ventilation. So intermittent suspension of mechanical ventilation under general anesthesia can ensure the surgery to be performed continuously and successfully. But this could result in hypercapnia and hypoxia. So far, there have been few studies focused on the change of the internal environment in blood as result of suspending breath. In this study, the investigators hypothesize that 10 cmH2O PEEP added to the respiratory circuit with 1 L/min 100% oxygen might extend the time of ventilation suspension but have no effect on carbon dioxide retention in blood.

Enrollment: 150 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

ASA I~III general anesthesia sign the informed consent

Exclusion criteria

ASA IV or V woman who is pregnant or plans to bear

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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150 participants in 2 patient groups, including a placebo group

with PEEP

Active Comparator group

Description:

10 cmH2O PEEP added to the respiratory curcuit during suspension of mechanical ventilation

Treatment:

Other: PEEP

without PEEP

Placebo Comparator group

Description:

0 cmH2O PEEP added to the respiratory curcuit during suspension of mechanical ventilation