SVF Therapy for Human Knee Osteoarthritis

Zhongnan Hospital

Status: Completed

Conditions: Knee Osteoarthritis

Treatments: Procedure: SVF treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT05019378

Zhongnanzxx

Details and patient eligibility

About

The purpose of the study is to asses the safety and efficacy of SVF for treatment of knee osteoarthritis, and establish a novel method to provide 3D MRI imaging for human knee cartilage to qualitatively and quantitatively evaluate cartilage regeneration.

Full description

Study participants voluntarily provided written informed consent to participate in the study. The two knees of each patient were randomly assigned to autologous SVF treatment group or non-treatment control group. The patients were evaluated every 4 weeks for safety and efficacy of autologous SVF therapy for 24 weeks.

Enrollment: 6 patients

Sex: All

Ages: 50 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of Knee Osteoarthritis
• Articular cartilage defect grades I/II of both knee

Exclusion criteria

• autoimmune or inflammatory arthritis
• serious medical disorders

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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6 participants in 2 patient groups

autologous SVF treatment

Experimental group

Description:

Three milliliter of cell suspension injection containing 1.0E8 SVF cells into the knee joint

Treatment:

Procedure: SVF treatment

Placebo group

No Intervention group

Description:

No treatment