SW-IMRT Versus ST-IMRT in the Treatment of Head and Neck Cancer

National Cancer Institute, Egypt

Status: Unknown

Conditions: Swallowing Dysfunction

Treatments: Radiation: ST-IMRT SW-IMRT

Study type: Interventional

Funder types: Other

Identifiers

NCT04597177

MD201001409.3

Details and patient eligibility

About

To clinically validate whether SW-IMRT actually reduce the occurrence of swallowing dysfunction as compared to ST-IMRT.

Full description

Patients are randomly assigned to either ST-IMRT or SW-IMRT.

Enrollment: 146 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with squamous cell carcinoma and requiring whole neck irradiation as a part of either definitive RT alone or in combination with chemotherapy or post-operative RT either alone or in combination with chemotherapy.

Exclusion criteria

• Previous radiotherapy to the head and neck region or prior malignancies, and/or distant metastases.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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146 participants in 2 patient groups

ST-IMRT

Active Comparator group

Description:

standard parotid sparing IMRT

Treatment:

Radiation: ST-IMRT SW-IMRT

SW-IMRT

Experimental group

Description:

swallowing sparing IMRT

Treatment:

Radiation: ST-IMRT SW-IMRT