Sweet Taste Responsiveness in Relation to Insulin, Leptin and Adiposity Among Obese Treatment Seeking Children

University at Buffalo (UB)

Status: Withdrawn

Conditions: Pediatric Obesity

Treatments: Diagnostic Test: Serum Leptin test; Diagnostic Test: Serum insulin level

Study type: Interventional

Funder types: Other

Identifiers

NCT04600648

00002306

Details and patient eligibility

About

This study will explore whether a relationship exists between insulin and leptin resistance, sweet taste responsiveness, and adiposity.

Full description

Compared to healthy weight peers, some reports have shown that they are less sensitive to, or perceptive of, sucrose solutions and sweet foods, whereas others have observed the opposite pattern of findings or no difference at all. Among those seeking weight loss treatment, one investigation found perception and preferences for sweet taste remained unchanged after weight loss, and another observed a decreased ability to distinguish sweet taste from other taste solutions. Given these discrepancies in the literature, the proposed study will explore whether a relationship exists between insulin and leptin resistance, sweet taste responsiveness, and adiposity.

Sex: All

Ages: 8 to 14 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient of Children's Healthy Weigh of Buffalo
• ages of 8-14

If enrolled in the bariatric arm:

• must be scheduled for bariatric surgery prior to enrollment

Exclusion criteria

• Patients unable to get labs drawn at a Kaleida facility
• Severe hay fever or seasonal allergies within 2 weeks of enrollment
• smoker or are exposed to second-hand smoke at home,
• has been dieting to lose weight within the past 6 months of enrollment
• currently taking any prescription medications that can influence taste or small functions or are pregnant.
• pregnancy
• Bariatric arm patients will be excluded if they fail to have the surgery.

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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0 participants in 2 patient groups

Weight loss with bariatric surgery

Active Comparator group

Description:

Patients scheduled to undergo bariatric surgery will be tested pre and post bariatric surgery. Interventions to be measured are serum Insulin and leptin levels, sweet taste responsiveness, body fat percentage, and z-BMI

Treatment:

Diagnostic Test: Serum insulin level

Weight Loss

Active Comparator group

Description:

Patients to receive lifestyle weight loss treatment will be tested pre and post bariatric surgery. Interventions to be measured are serum Insulin and leptin levels, sweet taste responsiveness, body fat percentage, and z-BMI

Treatment:

Diagnostic Test: Serum Leptin test