Swiss ProspectivE Cohort of TRAnsgender and Gender Diverse Individuals - the SPECTRA Study

University Hospital Basel

Status: Not yet enrolling

Conditions: Gender Incongruence; Transgender Individuals

Study type: Observational

Funder types: Other

Identifiers

NCT06774053

2025-00018

Details and patient eligibility

About

The goal of this observational study is to understand the factors influencing the well-being and health of transgender and gender-diverse (TGD) individuals undergoing gender-affirming therapies in Switzerland. The study population includes TGD individuals aged 16 and older, at various stages of their medical transition, including those who have discontinued or detransitioned.

The main question is:

What are the key factors influencing the well-being and health outcomes of transgender and gender-diverse individuals undergoing gender-affirming therapies?

Researchers will compare health outcomes across different subgroups, such as those at different stages of transition or detransition, to examine the effects of gender-affirming therapies.

Participants will:

Complete electronic questionnaires assessing gender congruence, quality of life, mental health, and other outcomes.

Provide biological samples (e.g., blood, urine, stool, and skin swabs) for laboratory analysis.

Undergo clinical evaluations related to endocrinology, fertility, dermatology, and urology as part of their routine follow-up.

Enrollment: 600 estimated patients

Sex: All

Ages: 16+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 16 years and above.
• Established diagnosis of gender incongruence
• Indication for gender affirming therapy or ongoing or discontinued gender affirming therapy

Exclusion criteria

• Unable to give informed consent
• Missing commitment or ability to study protocol adherence

Trial design

600 participants in 1 patient group

Cohort of Transgender and Gender Diverse individuals in Switzerland