Switching From Morphine to Oral Methadone Plus Acetaminophen in the Treatment of Cancer Pain

ABC Foundation (FUABC)

Status and phase: Unknown; Phase 3; Phase 2

Conditions: Cancer; Pain; Palliative Care

Treatments: Drug: Methadone plus Acetaminophen or Placebo

Study type: Interventional

Funder types: Other

Identifiers

NCT00525967

217/2005

Details and patient eligibility

About

The purpose of this study is to determine whether oral methadone plus acetaminophen can substitute morphine in the treatment of cancer pain.

Full description

Opioids are the mainstay of moderate-to-severe cancer pain management. Although morphine is the most commonly used, methadone has some advantages such as higher potency, lower cost and longer administration intervals. To minimize the time necessary to achieve the equianalgesic effect after a switching from morphine to methadone, acetaminophen was added in the treatment.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of cancer pain
• Regular use of oral Morphine

Exclusion criteria

• Use of Acetaminophen in the last 48 hours
• Renal or Hepatic failure

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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50 participants in 2 patient groups

1

Active Comparator group

Description:

Methadone plus Placebo

Treatment:

Drug: Methadone plus Acetaminophen or Placebo

2

Experimental group

Description:

Methadone plus Acetaminophen

Treatment:

Drug: Methadone plus Acetaminophen or Placebo