Switching to Duloxetine From Other Antidepressants

Lilly

Status and phase: Completed; Phase 4

Conditions: Major Depressive Disorder

Treatments: Drug: Duloxetine

Study type: Interventional

Funder types: Industry

Identifiers

NCT00191932

8604

F1J-MC-HMDG

Details and patient eligibility

About

A multicentre, randomised, open label study of out-patients with major depression who have failed to respond adequately to antidepressant treatment for their current episode of depression. The study compares outcomes associated with two methods of switching from current antidepressant to duloxetine

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Male and female outpatients of at least 18 years of age, who meet criteria for Major Depressive Disorder (MDD)
• Currently non- or only partially-responsive to an SSRI antidepressant after at least 5 weeks of treatment

Exclusion Criteria include:

• Current primary Axis I disorder other than MDD
• Previous diagnosis of bipolar disorder, schizophrenia, or other psychotic disorders
• Patients judged to be at serious suicidal risk.
• Serious medical illness

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)