Sympatholytic Effects of High Thoracic Erector Spinae Plane Block: Changes in Optic Nerve Sheath Diameter

Pamukkale University

Status: Not yet enrolling

Conditions: Complex Regional Pain Syndromes

Treatments: Procedure: thoracic erector spinae plane (ESP) block

Study type: Observational

Funder types: Other

Identifiers

NCT06468384

PAU-ANEST-SI-IC-01

Details and patient eligibility

About

The thoracic erector spinae plane (ESP) block is suggested to potentially affect the stellate ganglion, a key component of the sympathetic nervous system, thereby influencing autonomic functions. Changes in optic nerve sheath diameter (ONSD) are used as indicators of intracranial pressure changes. This study aims to investigate the effects of the ESP block on ONSD, providing insights into its impact on the stellate ganglion and enhancing the understanding of the ESP block's safety and efficacy.

Full description

The thoracic erector spinae plane (ESP) block is a regional anesthesia technique. This technique involves the injection of local anesthetics into the deep layers of the erector spinae muscles, blocking both somatic and visceral pain pathways. Although various studies have been conducted on the effectiveness of this technique in different clinical situations over the years, further research is needed to understand the precise mechanisms behind its neuroanatomical effects.

The stellate ganglion, an important component of the sympathetic nervous system, plays a crucial role in the regulation of several autonomic functions. It has been suggested that the ESP block may affect the stellate ganglion through its injection at the upper thoracic levels. Changes in the optic nerve sheath diameter (ONSD) have been used as an important indicator of intracranial pressure changes. Any potential changes in ONSD following stellate ganglion blockade could help elucidate the effects of the ESP block, thus aiding in the understanding of its safety and potential benefits for analgesia.

The aim of this study is to investigate the changes in optic nerve sheath diameter in patients undergoing the thoracic ESP block, which could provide more information on the impact of the ESP block on the stellate ganglion. By doing so, we aim to gain further insights into the potential analgesic effects and safety of the ESP block.

Enrollment: 15 estimated patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults with neck, shoulder, and arm pain
• Those with complex regional pain syndrome

The study will include 15 adult patients who are planned to receive T2-ESP block treatment.

• Age between 18-65 years
• Both genders
• ASA physical status I-II

Exclusion criteria

• Those who refuse procedures and tests
• Individuals with conditions that can increase intracranial pressure
• Those with severe heart failure
• Individuals with second or third-degree atrioventricular block
• Those with a history of unstable angina
• Individuals with COPD or chronic asthma
• Those who have experienced a myocardial infarction (MI) within the last 6 weeks
• Individuals with a heart rate below 50 beats per minute
• Those with systolic blood pressure below 90 mmHg
• Individuals with liver failure
• Those with kidney failure
• Individuals for whom a supraclavicular block is anatomically impossible
• Those with neurological or psychological conditions that complicate test evaluation
• Individuals allergic to any of the study medications
• Pregnant individuals

Trial design

15 participants in 1 patient group

Patients Undergoing Thoracic Erector Spinae Plane Block

Description:

The study focuses on a cohort of adult patients who are receiving the thoracic erector spinae plane (ESP) block for pain management. These patients include individuals experiencing pain in the shoulder, arm, or neck, as well as those with complex regional pain syndrome. The patients are generally healthy adults, categorized under ASA I-II (American Society of Anesthesiologists Physical Status Classification System). The primary aim of the study is to observe changes in optic nerve sheath diameter (ONSD) following the ESP block and to investigate the potential impact on the stellate ganglion. Data will be collected through clinical examinations and ultrasound performed before and after the ESP block procedure. The study aims to enhance understanding of the ESP block's safety and potential autonomic effects.

Treatment:

Procedure: thoracic erector spinae plane (ESP) block