Symptom Based Treatment of Neuropathic Pain

Ju Seok Ryu

Status and phase: Completed; Phase 4

Conditions: Spinal Cord Injury; Neuralgia

Treatments: Drug: Pregabalin and Oxcarbazepine

Study type: Interventional

Funder types: Other

Identifiers

NCT02180880

NeuropathicPain

Details and patient eligibility

About

1. Neuropathic pain in spinal cord injured patients

2. Inclusion criteria

   • pain intensity, visual analogue scale > 3
   • a LANSS (Leeds assessment of neuropathic symptoms and signs) score of 12 and above
   • aged ≥20

3. Method

   • Stop pain medications
   • Test oxcarbazepine (150mg twice daily) and pregabalin (150mg twice daily)
   • Check pain intensity (VAS score) with Baron's classification

Full description

In the present study, pharmacologic treatment included pregabalin and oxcarbazepine.

Stop medications such as Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), tramadol and anti-spastic drugs (baclofen, tizanidine) and other medications known to have effect on pain and the central nervous system prior to the study for at least 3 days.

1. Pain intensity (VAS score)

   1. 4 spontaneous characters

      • electric
      • burning
      • pricking
      • numbness

   2. evoked pain

      • allodynia
      • heat hyperalgesia
      • pressure hyperalgesia

2. Location of neuropathic pain

   1. neuropathic pain at level of spinal cord injury
   2. neuropathic pain below level of spinal cord injury

3. Side effects

Enrollment: 63 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• aged than 20 years
• Neuropathic pain symptoms : LANSS (Leeds assessment of neuropathic symptoms and signs) score of 12 and above
• Visual analogue scale score of 3 and above

Exclusion criteria

• No pregnancy
• systemic disease
• psychiatric disease

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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63 participants in 1 patient group

Pregabalin and Oxcarbazpepine

Experimental group

Description:

Pregabalin and Oxcarbazepine

Treatment:

Drug: Pregabalin and Oxcarbazepine