Symptomatic Efficacy of Diacerein in Knee Osteoarthritis

Laboratoires NEGMA

Status and phase: Completed; Phase 4

Conditions: Knee Osteoarthritis

Treatments: Drug: Diacerein

Study type: Interventional

Funder types: Industry

Identifiers

NCT00445276

HEC / ART 05 566 N

AFSSAPS:050984

CCPPRB:2005-27

Details and patient eligibility

About

Pain is the main symptom of osteoarthritis that motivates medical visits. Diacerhein has already demonstrated its efficacy in knee and/or hip osteoarthritis. This study aims at confirming the efficacy of diacerhein in symptomatic knee osteoarthritis using known and validated criteria and according to the recommendations and guidelines for this kind of study.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Painful primary osteoarthritis (VAS ≥ 40 mm)
• Radiologically proven (Kellgren & Lawrence grade I to III)
• Requiring the prescription of a symptomatic treatment of pain

Exclusion criteria

• Severe associated diseases
• Wash-out: AINS, Coxibs, Paracetamol, anti-osteoarthritic treatments, hyaluronic acid, knee tidal lavage
• Other osteoarticular disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind