Symptomatic Treatment of Acute Uncomplicated Diverticulitis

Helsinki University Central Hospital (HUCH)

Status: Completed

Conditions: Diverticulitis

Treatments: Drug: Paracetamol; Drug: Ibuprofen

Study type: Interventional

Funder types: Other

Identifiers

NCT02219698

HUS-Dnro122-2014

Details and patient eligibility

About

The purpose of this study is to determine the safety and efficacy of symptomatic treatment (i.e. without antimicrobial drugs) of acute uncomplicated diverticulitis.

Enrollment: 158 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Computed tomography-diagnosed acute uncomplicated* diverticulitis

  • No abscess, fistula, obstruction and distant intra- or retroperitoneal air. Pericolic air allowed.

Exclusion criteria

• Already commenced antimicrobial medication
• Immunosuppression (e.g. diabetes, corticosteroid medication, immunosuppressive medication, chemotherapy, chronic liver disease)
• Suspicion of generalized peritonitis
• Organ dysfunction
• Another infection requiring antimicrobial medication
• Pregnancy
• Age < 18 years or > 90 years
• Missing written consent

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

158 participants in 1 patient group

Symptomatic treatment

Experimental group

Treatment:

Drug: Paracetamol

Drug: Ibuprofen