Symptoms Burden in Lung Cancer Patients Undergoing Definitive Chemoradiotherapy: Insights From Electronic Patient-Reported Outcomes (ePRO-LC-CRT)

Qian Chu

Status: Enrolling

Conditions: Patient-Reported Outcomes (PRO); Lung Cancer; Chemoradiotherapy

Treatments: Other: Electronic Patient-Reported Outcome Monitoring

Study type: Observational

Funder types: Other

Identifiers

NCT07131670

TJ-IRB20240606

Details and patient eligibility

About

This prospective observational study aims to evaluate symptom burden and symptom clusters among lung cancer patients undergoing definitive concurrent chemoradiotherapy (CRT), based on electronic patient-reported outcomes (ePROs). Patients will complete the validated MDASI-LC and EQ-5D instruments weekly from baseline through the end of CRT and for 12 weeks post-treatment. The study will characterize the longitudinal trajectories of symptom severity and interference, identify distinct symptom clusters and their temporal patterns, and explore patient-level predictors of symptom burden. The findings may support the development of personalized symptom management strategies and improve quality of life during and after CRT.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Pathologically confirmed unresectable stage III NSCLC or limited-stage SCLC
• Age ≥ 18 years
• Receiving definitive chemoradiotherapy
• Able and willing to complete electronic questionnaires
• Provided written informed consent

Exclusion criteria

• Severe comorbidities (heart, liver, kidney)
• Psychiatric illness or cognitive impairment
• Prior chest or mediastinal radiotherapy

Trial design