Synchronizing Blastocyst in Frozen Embryo Transfer

Al-Yasmeen Fertility and Gynecology Center

Status: Completed

Conditions: Embryo Implantation

Treatments: Other: synchronizing blastocysts

Study type: Interventional

Funder types: Other

Identifiers

NCT03128970

001-2017

Details and patient eligibility

About

The aim of the present study is to determine if implantation rate could be increased in women undergoing frozen embryo transfer cycles in case of adjusting their embryo development at hatching stage.

Enrollment: 742 patients

Sex: Female

Ages: 19 to 33 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients who will agree to participate and assign an informed consent form
2. Only blastocyst transfer FET cycles
3. Patients undergoing FET after their 1st IVF or ICSI cycle with no pregnancy at the fresh transfer
4. Freeze-all cycles due to OHSS
5. Freeze-all cycles due to poor endometrium
6. Age 19-33 at the time of randomization.
7. Their frozen blastocysts are 3 or less grade of expansion.
8. Female with a ≥12 AFCs
9. Endometrial thickness ≥ 8mm at the time of ovulation
10. Women with their male partners will give only fresh semen
11. Women who have no uterine abnormality by ultrasound
12. BMI ≤ 31

Exclusion criteria

1. Cycles undergoing preimplantation genetic diagnosis.
2. Women who have previous two cycles of implantation failure at fresh transfer
3. Women who have previous two FET failed cycles
4. Any uterine pathology (myomas, adenomyosis, endocrinopathies, thrombophilia, chronic pathologies, acquired or congenital uterine abnormalities)
5. Patients with severe endometriosis
6. Presence of uni- or bilateral hydrosalpinx
7. Recurrent pregnancy loss.
8. Any medical condition that affect fertility.

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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742 participants in 2 patient groups

frozen/thawed

No Intervention group

Description:

blastocysts with three or less grade of expansion will be thawed and then subsequently transferred into women uterus three hours post-thawing.

synchronized frozen/thawed hatching blastocysts

Experimental group

Description:

blastocyst thawing (with three or less grade of expansion) will take place the day before embryo transfer in order to reach hatching stage

Treatment:

Other: synchronizing blastocysts