Syncytiotrophoblast-derived Extracellular Vesicles in Placenta Previa and Accreta Spectrum (PAS)

Institute of Hospitalization and Scientific Care (IRCCS)

Status: Enrolling

Conditions: Placenta Previa; Placenta Accreta Spectrum

Treatments: Procedure: Blood sample

Study type: Interventional

Funder types: Other

Identifiers

NCT06867874

5606

Details and patient eligibility

About

The main goal of this case-control study is to quantify the levels of circulating syncytiotrophoblast-derived extracellular vesicles (STBEVs) in maternal blood in a population of women with placenta previa and placenta accreta spectrum.

Full description

The main goal of this case-control study is to quantify the levels of circulating syncytiotrophoblast-derived extracellular vesicles (STBEVs) in maternal blood in a population of women with ultrasound diagnosis of PP with and without postpartum histopathologic diagnosis of PAS, compared to pregnant women with normal placentation.

The secondary aim of this case-control study is to characterize the multi-omics profiling of STBEVs cargo's (proteins, gene and transcripts) isolated from patients diagnosed with PP and PAS compared to the control population.

Enrollment: 70 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Pregnant women with diagnosis of placenta previa and accreta spectrum (cases)
• Healthy pregnant women
• > 18 years

Exclusion criteria

• < 18 years
• Twin pregnancies
• Chronic Infections
• Cancers
• Unable to give the written consent

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

70 participants in 1 patient group

Women with diagnosis of PP and PAS

Experimental group

Description:

Pregnant women with abnormal placentation as placenta previa and accreta spectrum

Treatment:

Procedure: Blood sample