Synergistic Effects of Anxiety and Alcohol Use Among Latinos and Its Sociocultural Mechanisms

University of Houston

Status: Completed

Conditions: Alcohol Drinking; Racism

Treatments: Other: Placebo; Other: No Alcohol; Other: Alcohol administration

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT03807817

1K23AA025920-01A1

Details and patient eligibility

About

The purpose of this study is to examine the pharmacological effects of alcohol on acute anxiety levels in a sample of Latino drinkers, and cultural experiences influencing these relationships.

Enrollment: 99 patients

Sex: All

Ages: 21 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. 21-65 years of age
2. moderate or heavy drinker based on a past-month AUDIT score >= 8.

Exclusion criteria

1. Possibility of being pregnant (verified by urine sample);
2. Self-reported history of or treatment for alcohol/other drug problems (as required by the IRB in past human alcohol administration research);
3. Moderate risk for drug problems as indicated by SMAST scores ≥ 5 or ASSIST scores of ≥ 4 (see Measures);
4. Medical conditions that contraindicate the use of alcohol (e.g., diabetes, liver disease);
5. Current use of psychiatric meds or any meds with alcohol contraindication (e.g., antibiotics);
6. Current non-alcohol substance use disorder;
7. Active suicidality (i.e., suicidal ideation, intent, and/or plan) or current psychosis.

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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99 participants in 4 patient groups

Moderate Alcohol

Experimental group

Treatment:

Other: Alcohol administration

Low Alcohol

Experimental group

Treatment:

Other: Alcohol administration

Placebo Alcohol

Active Comparator group

Treatment:

Other: Placebo

No Alcohol

Active Comparator group

Treatment:

Other: No Alcohol