Synovial Fluid Analysis of Intraarticular Elbow Fracture

Duke University

Status: Completed

Conditions: Joint Contracture; Elbow Fracture

Treatments: Procedure: Synovial Fluid Analysis

Study type: Interventional

Funder types: Other

Identifiers

NCT02878941

Pro00072559

Details and patient eligibility

About

The objective of this study is to obtain and compare bilateral elbow joint synovial fluid from patients with unilateral intraarticular elbow fracture and a contralateral healthy appearing elbow joint. The synovial fluid samples will undergo several forms of analysis for metabolites and proteins. Matched-pair statistical analysis will be performed to determine the metabolites and proteins that may play the greatest role in development of joint contracture.

Enrollment: 12 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18 years and older
• Intraarticular elbow fracture (humerus, radial head and/or ulna fracture)

Exclusion criteria

• Age <18 years
• Open elbow fracture
• Bilateral elbow fractures
• Patients with history of osteomyelitis of elbow
• Inflammatory arthropathy (ie. Rheumatoid arthritis)
• Prior surgery on fractured elbow

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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12 participants in 1 patient group

Elbow Fracture

Other group

Description:

Patients with an intraarticular elbow fracture and/or dislocation. Synovial fluid from the injured elbow will be obtained during the subject's emergency department encounter by one of the Chief Residents or Attending surgeon as part of standard of care procedures for pain control-related injection and aspiration. Patients with an intraarticular elbow fracture and/or dislocation receive an intraarticular elbow injection with anesthetic (i.e. lidocaine or marcaine) to provide analgesia for elbow range of motion testing and orthopaedic reduction maneveuers as the current standard of care. The patients would be asked to consent for 2 elbow joint aspirations: 1.Aspiration of the injured elbow at time of surgical fracture fixation; 2.Aspiration of the uninjured elbow at time of surgical fracture fixation.

Treatment:

Procedure: Synovial Fluid Analysis