Synovitis in Patients With Osteoarthritis

Qingdao University

Status: Completed

Conditions: Osteoarthritis, Knee

Treatments: Procedure: Total knee arthroplasty due to advanced osteoarthritis.

Study type: Observational

Funder types: Other

Identifiers

NCT05617573

OASynoviumAHQD

Details and patient eligibility

About

To study synovial membrane (SM) inflammation in suprapatellar fossa in advanced knee osteoarthritis (OA), and to correlate the pathological features with clinical findings.

Enrollment: 272 patients

Sex: All

Ages: 55 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients undergoing elective, unilateral, primary TKA for advanced osteoarthritis.

Exclusion criteria

• revisions, bilateral procedures, alcohol or medical abuse, administration of any glucocorticoids during the 3 months prior to surgery, and/or a history of serious cardiac or cerebrovascular problems, severe liver or kidney failure, and/or connective tissue disease including rheumatoid arthritis, ankylosing spondylitis, and systemic lupus erythematosus.

Trial design

272 participants in 1 patient group

Patients undergone TKA due to advanced knee osteoarthritis

Treatment:

Procedure: Total knee arthroplasty due to advanced osteoarthritis.