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System for Determining Ideal Drug Doses for ADHD - Stages 1 and 2

University of Wisconsin (UW) logo

University of Wisconsin (UW)

Status

Terminated

Conditions

Attention Deficit Hyperactivity Disorder

Treatments

Other: no intervention. measure eye movement data

Study type

Observational

Funder types

Other

Identifiers

NCT03523663
Protocol Version 8/1/2019 (Other Identifier)
2015-0857
A536200 (Other Identifier)
SMPH\DPT NEUROSCIENCE (Other Identifier)

Details and patient eligibility

About

The goal of this study is to create a formal, quantitative methodology to determine what is the most beneficial dose of Central Nervous System (CNS) stimulant (Ritalin, methylphenidate) to improve cognitive and behavioral function of children diagnosed with Attention Deficit Hyperactivity Disorder (ADHD) individually. If successful, it will change the way in which the dose of CNS stimulant for treating ADHD is determined for children in need of therapeutic intervention. The project will be focused on developing the necessary methodology to analyze the children's data with the drift-decision model (DDM), and to develop the required technology, i.e., a computer game with which to measure cognitive/behavioral function and its validation with eye-tracking measurements.

Enrollment

46 patients

Sex

All

Ages

8 to 12 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • 8-12 years of age;
  • Accompanied by caregiver (parent or legal guardian);
  • Able to understand and speak English;
  • Able to read basic English;
  • No counseling or current/past history of psychiatric illness, as confirmed by the Child Behavior Checklist (CBCL) and Conner's rating scale

Exclusion criteria

  • Active psychosis or suicidality
  • History of primary psychotic disorder (e.g., schizophrenia) or bipolar disorder
  • Recent (past 2 weeks) substance abuse or dependence
  • History of brain damage or significant developmental delay
  • Unstable medical condition such as newly diagnosed Type I Diabetes or Rheumatoid arthritis
  • Use of oral steroids
  • Participation in the last 30 days in a clinical study involving an investigational drug
  • Current use of a psychotropic medicine

Trial design

46 participants in 2 patient groups

Control
Description:
healthy children without ADHD or other mental health issues
Treatment:
Other: no intervention. measure eye movement data
ADHD
Description:
children diagnosed with ADHD
Treatment:
Other: no intervention. measure eye movement data

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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