Systemic Cross-talk Between Brain, Gut, and Peripheral Tissues in Glucose Homeostasis: Effects of Exercise Training (CROSSYS)

U

University of Turku

Status

Completed

Conditions

Exercise Training
Type2 Diabetes
Insulin Resistance
Obesity

Treatments

Behavioral: Exercise training

Study type

Interventional

Funder types

Other

Identifiers

NCT03730610
317332

Details and patient eligibility

About

Obesity and insulin resistance are worldwide epidemic and taking a major public health toll. Obesity also increases the risk for cognitive impairment which is also an increasing medical, societal, and economic challenge. The ultimate goal of this proposal is to develop a statistical model to assess systemic cross-talk between brain, peripheral tissues, gut microbiota and glucose metabolism. Integrated with exercise training intervention the results will be utilized to provide disease risk profiling and personalized predictions of exercise training as a drug free treatment for insulin resistance and type 2 diabetes.

Enrollment

24 patients

Sex

All

Ages

30 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • monozygotic twins
  • body mass index (BMI) difference ≥ 2 kg/m2 and/or type 2 diabetes
  • At least one co-twin is overweight (BMI > 25 kg/m2)

Exclusion criteria

  • BMI > 60 kg/m2
  • body weight > 170 kg
  • waist circumference > 150 cm
  • mental disorder or poor compliance
  • eating disorder or excessive use of alcohol
  • active ulcus disease
  • diabetes requiring insulin treatment or fasting glucose > 10 mmol/l
  • pregnancy
  • past dose of radiation
  • claustrophobia
  • presence of ferromagnetic objects that would make MRI contraindicated

Trial design

Primary purpose

Prevention

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

24 participants in 1 patient group

Exercise intervention
Experimental group
Description:
Six months of exercise training
Treatment:
Behavioral: Exercise training

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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