Systemic Effects of Epidural Methylprednisolone Injection on Glucose Tolerance in Diabetic Patients

Vaud University Hospital Center

Status: Completed

Conditions: Healthy; Diabetes

Treatments: Drug: intra-articular infiltration; Drug: epidural infiltration

Study type: Interventional

Funder types: Other

Identifiers

NCT01420497

gylperi

Details and patient eligibility

About

Several studies have shown that in diabetic patients, the glycemic profile was disturbed after intra-articular injection of corticosteroids. Little is known about the impact of epidural injection in such patients. The goal of this study was double, at first comparing the glycaemic profile in diabetic patients after a unique injection of 80 mg of acetate methylprednisolone either intra-articular or epidural, secondly to compare the amount of systemic diffusion of the drug the after both procedures.

Enrollment: 25 patients

Sex: All

Ages: 20 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• diabetes stable for more than ten days
• no contraindication for steroids
• lumbar stenosis
• articular pain

Exclusion criteria

• unstable diabetes
• renal insufficiency

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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25 participants in 2 patient groups

methylprednisolone,infiltration

Active Comparator group

Treatment:

Drug: intra-articular infiltration

epidural injection

Active Comparator group

Treatment:

Drug: epidural infiltration