Systemic Immune Inflammatory Index in Systemic Lupus Erythematosus

Sohag University

Status: Enrolling

Conditions: Lupus Nephritis; Systemic Lupus Erythematosus

Treatments: Diagnostic Test: systemic immune inflammatory index

Study type: Observational

Funder types: Other

Identifiers

NCT06796569

soh-Med-25-1-2MD

Details and patient eligibility

About

This study aims to investigate the association between the systemic immune-inflammation index and disease activity, as well as lupus nephritis in patients with systemic lupus erythematosus

Enrollment: 90 estimated patients

Sex: All

Ages: 16+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• o Older than 16 years

  • In a patient with SLE, patients who fulfill the criteria of the American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR).
  • In patients with LN, patients whose diagnosis is confirmed by kidney biopsy and pathohistological verification (WHO classification, and the International Society of Nephrology/Renal Pathology Society (ISN/RPS) classification.

Exclusion criteria

• Patients with other autoimmune rheumatological diseases, lymphoproliferative disorders, malignancies, liver diseases, end-stage kidney disease, diabetic nephropathy, active infections, recent history of blood transfusion and patients with deficiencies in vitamin B12, folate, and iron are excluded from the study.

Trial design

90 participants in 3 patient groups

patients diagnosed with systemic lupus and lupus nephritis

Description:

this group will include 30 patients, all patients will undergo the following: For the evaluation of SLE clinical disease activity SLEDAI ( systemic upus erythematosus disease activity index)scores will be recorded The SII (systemic immune inflammatory index) will be calculatedusing the following formula: SII = (neutrophil count × platelet count)/lymphocyte count.

Treatment:

Diagnostic Test: systemic immune inflammatory index

patients diagnosed with systemic lupus without lupus nephritis

Description:

this group will also include 30 patients, all patients will undergo the following: For the evaluation of SLE clinical disease activity SLEDAI ( systemic upus erythematosus disease activity index)scores will be recorded The SII (systemic immune inflammatory index) will be calculated using the following formula: SII = (neutrophil count × platelet count)/lymphocyte count.

Treatment:

Diagnostic Test: systemic immune inflammatory index

healthy control group

Description:

this group will also include 30 healthy controls , they will undergo the following: The SII (systemic immune inflammatory index) will be calculated using the following formula: SII = (neutrophil count × platelet count)/lymphocyte count.

Treatment:

Diagnostic Test: systemic immune inflammatory index