Systemic Inflammation Versus Acute Pain in Total Knee Arthroplasty (TKA)

Hvidovre University Hospital

Status: Completed

Conditions: Systemic Inflammatory Response Syndrome; Other Acute Postoperative Pain

Study type: Observational

Funder types: Other

Identifiers

NCT01322074

9991999

Details and patient eligibility

About

In this study we evaluate if there is a correlation between acute pain and systemic inflammatory markers after total Knee Arthroplasty (TKA).

Full description

The correlation between acute pain and systemic inflammatory markers after total Knee Arthroplasty (TKA) is evaluated.

Level of systemic inflammatory markers (CRP and IL6) are measured preoperatively and 4 and 24 hours postoperatively. These measurements are correlated to postoperative pain (a detailed assessment of pain at rest and during ambulation).

We pole blood-samples collected prospectively (from two data set)

Enrollment: 120 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Elective unilateral primary total knee arthroplasty
• Able to speak and understand danish
• Able to give informed consent

Exclusion criteria

• Alcohol or medical abuse
• Allergies to local anesthetics or methylprednisolone
• Age < 18 years old
• Daily use of strong opioids or glucocorticoids
• Pregnancy or breastfeeding (fertile women)
• Bilateral / revision arthroplasty
• Dementia or other cognitive dysfunction
• Diabetic neuropathy, rheumatoid arthritis, and neurologic or psychiatric diseases potentially influencing pain perception

Trial design

120 participants in 1 patient group

Total knee arthroplasty

Description:

Patients operated with elective, unilateral total knee arthroplasty.