Systemic Inflammatory Response Syndrome (SIRS) in Patients Undergoing Major Procedures in Oral and Maxillofacial Surgery

University of Cologne

Status: Completed

Conditions: Systemic Inflammatory Response Syndrome (SIRS)

Study type: Observational

Funder types: Other

Identifiers

NCT01921049

13-229

Details and patient eligibility

About

Patients undergoing major procedures in oral and maxillofacial surgery more often develop a systemic inflammatory response syndrome (SIRS) in the first days of postoperative critical care therapy than patients with a comparable major surgery in other regions. The reasons for this finding are unknown and have not been studied in depth so far. We hypothesize that surgical trauma in this region might activate pro-inflammatory pathways. By examining the proteome of patients at different stages (prior to the surgery, at ICU admission, on the second postoperative day and when SIRS has ended clinically), we aim to identify the involved pro-inflammatory pathways and identify possible target proteins that might be clues to modification of postoperative SIRS in the future.

Enrollment: 27 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• age 18-99yrs
• scheduled for elective surgery with risk for development of SIRS
• written and informed consent

Exclusion criteria

• age <18yrs
• pregnancy
• emergency surgery
• failure to obtain patient consent