Systemic Therapy in Combination With Stereotactic Radiotherapy in Patients With Metastatic Colorectal Cancer up to 10 Metastatic Sites (SIRIUS)

UMC Utrecht

Status and phase

Not yet enrolling

Phase 2

Conditions

Metastatic Colorectal Cancer

Oligometastatic Disease

Treatments

Drug: Maintenance therapy (CAP-B or 5-FU/LV plus bevacizumab.)

Radiation: Stereotactic body radiation therapy (SBRT)

Study type

Interventional

Funder types

Other

Identifiers

NCT05375708

NL76444.041.21

Details and patient eligibility

About

A small number of colorectal cancer patients with limited oligometastases may be candidates for local treatment of metastases (e.g., resection, ablation). However, it is unclear if patients with more extensive metastatic disease benefit from local therapies to control visible metastasis.

The purpose of this study is to assess the impact of stereotactic body radiation therapy (SBRT) in combination with systemic therapy compared to systemic therapy alone on safety and efficacy in patients with metastatic colorectal cancer (mCRC) and ≤10 metastases.

Full description

The addition of stereotactic body radiation therapy (SBRT) to metastases in a limited unresectable metastatic setting might improve progression-free survival (PFS). The success of the addition of local treatments in mCRC patients depends largely on: control of microscopic disease, diagnostic accuracy of macroscopic disease and effective treatment of all detected metastases with limited additional toxicity to surrounding tissues. Until shortly, the use of SBRT was possible to a limited number of locations due to target movement or toxicity to surrounding radiosensitive structures. With the introduction of MRI-guided radiotherapy these limitations have been largely reduced due to the possibility to make a daily new treatment plan based on MRI-visualized anatomy. This allows the use of smaller margins for uncertainty with less healthy tissues in the radiation field. Thereby, a broader application of SBRT to add local control to metastases became possible.

This study is an open-label, multicenter, randomized phase II screening trial assessing the impact of SBRT in combination with systemic therapy compared to systemic therapy alone on safety and efficacy in patients with mCRC and ≤10 metastases with no option of local treatment with curative intent and with stable disease or partial response after treatment of CAPOX-B, FOLFOX-B or FOLFOXIRI-B.

Enrollment

93 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Registered in the prospective Dutch colorectal cancer cohort (PLCRC)
Intention at start of palliative systemic therapy to receive six maximum tolerated dose (MTD) cycles of CAPOX-B or eight MTD cycles of FOLFOX-B or FOLFOXIRI-B.
Ten or less metastases as determined by the university medical center Utrecht (UMCU) central review
Stable disease or partial response after initial chemotherapy according to RECIST 1.1 criteria.
Expected adequacy of follow-up
World Health organization (WHO) performance status 0-1
Life expectancy >12 weeks
Adequate organ functions at start of initial therapy, as determined by normal bone marrow function (Hb≥6.0 mmol/L, absolute neutrophil count ≥1.5 x 10^9/L, platelets ≥100 x 10^9/L), renal function (serum creatinine ≤ 1.5x upper limit of normal (ULN) and creatinine clearance, Cockcroft formula, ≥30 ml/min) and liver function (serum bilirubin ≤ 2 x ULN, serum transaminases ≤ 3 x ULN without presence of liver metastases or ≤ 5x ULN with presence of liver metastases)
Written informed consent (SIRIUS)

Exclusion criteria

Less than three cycles of CAPOX-B or four cycles of FOLFOX-B or FOLFOXIRI-B (dose reductions allowed).
More than six cycles of CAPOX-B or eight cycles of FOLFOX-B of FOLFOXIRI-B.
Possible treatment with curative intent according to local tumor board
Substantial overlap with a previously treated radiation volume. Previous radiotherapy is allowed as long as the composite plan meets dose constraints herein.
Not amenable for radiotherapy (e.g. peritonitis carcinomatosa)
Previous systemic treatment for metastatic disease; prior adjuvant treatment for stage II/III colorectal cancer when given >6 months before the start of initial systemic treatment is allowed.
Serious comorbidity or any other condition preventing the safe administration of treatment (including both systemic treatment and radiation)
Pregnant or lactating women
Other malignancy interfering with prognosis
Any concomitant experimental treatment.
Contra-indication MR-LINAC (pacemaker or implantable cardioverter-defibrillator)
Microsatellite instability or deficient mismatch repair tumor