Systemic Thrombolysis Versus Catheter Directed Management for Acute Intermediate-high Pulmonary Embolism

Assiut University

Status: Not yet enrolling

Conditions: Acute Pulmonary Embolism

Treatments: Device: Penumbra System; Drug: Streptokinase Injection

Study type: Observational

Funder types: Other

Identifiers

NCT06545864

123456@qerty

Details and patient eligibility

About

To compare in hospital clinical outcomes and one month follow up of systemic thrombolysis versus catheter directed management for the treatment of acute intermediate- high risk pulmonary embolism (using streptokinase or tissue plasminogen activator (TPA) and catheter-based intervention group using Penumbra System).

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

Patients diagnosed with acute intermediate-high pulmonary embolism

Exclusion criteria

• Patients less than 18 years of age.
• Low risk, intermediate low risk, acute pulmonary embolism
• patients with RV masses will be excluded.
• Patient refusal of treatment strategy.

Trial design

50 participants in 2 patient groups

patients who received systemic thrombolysis

Description:

patients have been diagnosed with acute intermediate-high pulmonary embolism received I.V. streptokinase if there are no contraindications.

Treatment:

Drug: Streptokinase Injection

patients who underwent catheter-based intervention

Description:

patients have been diagnosed with acute intermediate-high pulmonary embolism underwent catheter-based intervention including thrombus aspiration or catheter directed thrombolysis using Penumbra System

Treatment:

Device: Penumbra System