Systemic Transthyretin Amyloidosis: Carpal Tunnel Syndrome in a Portuguese Population (CarPoS)

Universidade do Porto

Status: Enrolling

Conditions: Transthyretin Amyloidosis; Carpal Tunnel Syndrome

Treatments: Diagnostic Test: Synovial biopsy and Cardiac scintigraphy with [99mTc]Tc-DPD

Study type: Observational

Funder types: Other

Identifiers

NCT05409833

CarPoS

Details and patient eligibility

About

Systemic transthyretin amyloidosis is an aging-related disorder. It is usually associated with cardiac disease but also extends to other organs. Recent studies found that idiopathic carpal tunnel syndrome patients may have amyloid deposition in tenosynovial tissue. The main aims of this project are the characterization of the association between idiopathic carpal tunnel syndrome and transthyretin amyloidosis and its evaluation as a predictive factor of cardiac amyloidosis

Enrollment: 100 estimated patients

Sex: All

Ages: 60+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

. Patients aged ≥ 60 years old with symptomatic idiopathic carpal tunnel syndrome or other hand surgery indications.

Exclusion criteria

. Diabetes mellitus, hypothyroidism, hemodialysis, rheumatoid arthritis, and other inflammatory arthropathies, multiple myeloma, gout, chondrocalcinosis, Colles fracture, space-occupying lesions, and infectious synovitis.

Trial design

100 participants in 2 patient groups

Group 1

Description:

Patients aged ≥ 60 years old with symptomatic carpal tunnel syndrome submitted to surgery

Treatment:

Diagnostic Test: Synovial biopsy and Cardiac scintigraphy with [99mTc]Tc-DPD

Group 2

Description:

Patients aged ≥ 60 years old without symptomatic carpal tunnel syndrome submitted to hand surgery

Treatment:

Diagnostic Test: Synovial biopsy and Cardiac scintigraphy with [99mTc]Tc-DPD