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Systems Analysis and Improvement to Optimize pMTCT

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University of Washington

Status

Completed

Conditions

HIV

Treatments

Other: pMTCT systems analysis and improvement

Study type

Interventional

Funder types

Other
NIH

Identifiers

NCT02023658
R01HD075057 (U.S. NIH Grant/Contract)
44167-EG

Details and patient eligibility

About

Despite significant increases in global health investment and the availability of low-cost, efficacious interventions designed to reduce mother to child HIV transmission in low and middle income countries with high HIV burden, the translation of these scientific advances into effective delivery strategies has been slow, uneven and incomplete. As a result, pediatric HIV infection remains largely uncontrolled. Enhancing the implementation of pMTCT interventions through contextually appropriate systems analysis and improvement approaches can potentially reduce drop-offs along the pMTCT cascade, leading to dramatic improvements in infant and maternal outcomes. The goal of this proposal is to develop a model for systematic assessment and improvement of pMTCT services in sub-Saharan Africa. In specific aim 1, we will identify health system factors and service delivery approaches associated with high and low performing pMTCT services in Côte d'Ivoire, Kenya and Mozambique. In specific aim 2 we will adapt evaluate the feasibility and impact of a systems analysis tool and associated performance enhancement approach for pMTCT services in Côte d'Ivoire, Kenya and Mozambique. This systems analysis tool and associated performance enhancement approach is currently being developed and piloted for pMTCT services in Mozambique. The results of this implementation research are expected to generate knowledge of global health significance, and by disseminating the study results and intervention tools through the broad PEPFAR network, can rapidly impact pMTCT service delivery enhancements across the highest need countries.

Enrollment

36 patients

Sex

Female

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • health facility with pMTCT services in central Mozambique, northern Cote d'Ivoire or western Kenya
  • health facility with at least 20 HIV-infected women identified in antenatal care per year

Exclusion criteria

  • health facility over 20 kilometers from a main transport corridor
  • health facility with an ongoing prospective study or systems analysis and improvement approach in place

Trial design

Primary purpose

Health Services Research

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

36 participants in 2 patient groups

Systems analysis and improvement
Experimental group
Description:
pMTCT systems analysis and improvement
Treatment:
Other: pMTCT systems analysis and improvement
Control
No Intervention group
Description:
No systems analysis and improvement intervention for prevention of mother to child HIV transmission services in place.

Trial contacts and locations

3

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Data sourced from clinicaltrials.gov

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