Systems Biology of Gastrointestinal and Related Diseases

Viome

Status: Terminated

Conditions: Gastritis; SIBO; Esophageal Cancer; Intestinal Metaplasia; Gastro Esophageal Reflux; Celiac Sprue; Gastric Ulcer; Obesity; NAFLD; Microscopic Colitis; Duodenal Ulcer; Irritable Bowel Syndrome; Gastric Cancer; Lymphocytic Colitis; Eosinophilic Esophagitis; Barrett Esophagus; IBS; GERD; Colon Polyp; Ulcerative Colitis; Crohn Disease; Gallstone Disease

Study type: Observational

Funder types: Industry

Identifiers

NCT05579444

V263

Details and patient eligibility

About

This is a longitudinal observational study on patients with gastrointestinal and related disease. The study will be conducted for at least 10 years, following each participant over time, as they either go through relapses and remissions, or progression of their disease.

Full description

This is a longitudinal, observational study whose main goal is to identify the human and microbial determinants of gastrointestinal diseases. Molecular and metadata will be collected from a large study population at multiple time points. Machine learning will be applied to all data, and models will be evaluated for development of novel diagnostic and therapeutic tools.

Enrollment: 17 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria

• Any patient 18 years old or older that schedules a visit to WAGI clinics or endoscopy center
• Able to use electronic communications
• Able to communicate in English
• Consent to participate in the study

Exclusion Criteria:

• None

Trial design

17 participants in 17 patient groups

Ulcerative Colitis

Description:

Participants with ulcerative colitis.

Crohn's Disease

Description:

Participants with Crohn's disease.

Obesity

Description:

Participants that are obese.

Colon Polyps

Description:

Participants with colon polyps.

Eosinophilic esophagitis

Description:

Participants with Eosinophilic esophagitis

Gastroesophageal Reflux Disease (GERD)

Description:

Participants with Gastroesophageal Reflux Disease (GERD).

Gastritis

Description:

Participants with gastritis.

Gastric ulcers

Description:

Participants with gastric ulcers.

Duodenal ulcers

Description:

Participants with duodenal ulcers.

Intestinal metaplasia

Description:

Participants with intestinal metaplasia (risk factor for esophageal cancer).

Gastric Cancer

Description:

Participants with gastric cancer.

Lymphocytic/Microscopic Colitis

Description:

Participants with Lymphocytic/Microscopic Colitis.

Celiac Sprue

Description:

Participants with Celiac Sprue.

Irritable Bowel Syndrome (IBS)

Description:

Participants with IBS.

Small intestinal bacterial overgrowth (SIBO)

Description:

Participants with SIBO.

Non-alcoholic Fatty Liver Disease (NAFLD)

Description:

Participants with NAFLD.

Gallstone disease

Description:

Participants with Gallstone disease.