T Cell Profiling in Patients with Multiple Sclerosis

Boston Children's Hospital

Status: Not yet enrolling

Conditions: Multiple Sclerosis

Treatments: Other: Blood Sample

Study type: Observational

Funder types: Other

Identifiers

NCT04789551

IRB-P00037843

Details and patient eligibility

About

The goal of this research study is to to learn more about the body's immune response in patients with multiple sclerosis (MS). In MS, the body's immune cells mistakenly attack an important part of the nerves of the brain and spinal cord. The immune cells responsible for attacking the nerves in MS patients is primarily the T cells. A marker was recently discovered that might specifically identify these damaging T cells from all other T cells in the body. Understanding which T cells cause the damage in MS patients and understanding more about these specific T cells may help doctors better understand how MS occurs and could possibly prevent MS in the future.

Enrollment: 40 estimated patients

Sex: All

Ages: 13 to 20 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

MS Group Inclusion criteria

-diagnosis of multiple sclerosis and present to the neurology clinic for a regular checkup or are admitted to the inpatient floor with acute symptoms.

Exclusion criteria

• Have an active infection
• Take T cell modulating drugs

Control Group Inclusion criteria -scheduled for elective surgery

• without any immunological diseases. Exclusion criteria
• Have an active infection.

Trial design

40 participants in 3 patient groups

Multiple Sclerosis Stable Conditions

Description:

Multiple sclerosis patients presenting for a routine clinic visit.

Treatment:

Other: Blood Sample

Multiple Sclerosis Acute Flare Up

Description:

Multiple sclerosis patients admitted to the hospital with acute symptoms.

Treatment:

Other: Blood Sample

Control patients

Description:

Patients without any immunological diseases who present for elective surgery.

Treatment:

Other: Blood Sample