T Central Memory Cells in Early Localized Non-Segmental Vitiligo

Cairo University (CU)

Status: Completed

Conditions: Vitiligo

Treatments: Drug: Topical cream; Device: targeted phototherapy; Drug: oral mini pulse

Study type: Interventional

Funder types: Other

Identifiers

NCT05706636

V-1-23

Details and patient eligibility

About

Assessing the level of circulating TCMs (cluster of differentiation (CD) 8+, CD3+,C- chemokine receptor (CCR)7, cluster of differentiation 45 receptor (CD45R) cells) in early localized vitiligo cases prior to treatment and after treatment in comparison to healthy controls. This, in turn, would provide insights regarding the role of TCMs in vitiligo and the role of early treatment in halting disease progression and autoimmune memory formation that accounts for high recurrence rate of vitiligo

Full description

Assessing the level of circulating TCMs (CD8+ CD3+ CCR7+ CD45RO+ cells) in early localized vitiligo cases where samples will be processed and stained for CD8, CD3, CCR7, . CCR7, CD45R. Multi-parametric flow cytometry will be used to quantify CD3+ve, CD8+ve, CCR7+ve, CD45RO+ve TCM cells percentage, which will be expressed as a percentage from the total lymphocyte gate. This will be done prior to treatment and after treatment and will be compared to healthy controls.

Enrollment: 22 patients

Sex: All

Ages: 12 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Subjects with vitiligo localized to one anatomical area, of ≤ 6 months' duration

Exclusion criteria

• Patients who received treatment of any type (topical or systemic) within the last 3 months

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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22 participants in 2 patient groups

Early localized vitiligo on topical treatment

Active Comparator group

Description:

Cases will only receive topical steroids/ calcineurin inhibitors and targeted phototherapy

Treatment:

Device: targeted phototherapy

Drug: Topical cream

Early localized vitiligo on topical and systemic treatment

Active Comparator group

Description:

Cases will receive oral mini-pulse steroids, topical steroids/ calcineurin inhibitors and targeted phototherapy

Treatment:

Drug: oral mini pulse

Device: targeted phototherapy

Drug: Topical cream