T-mult: Exploring the Impact of TMS Induced Virtual Lesions on the Multimodal Brain Network and Cognition

Amsterdam UMC, location VUmc

Status: Completed

Conditions: Healthy Cognition

Treatments: Device: repetitive transcranial magnetic stimulation (rTMS)

Study type: Interventional

Funder types: Other

Identifiers

NCT05542641

NL82268.029.22

Details and patient eligibility

About

T-mult is an experimental study using low-frequency (1Hz) single-sesson rTMS to the DLPFC (versus sham rTMS) to explore the effect of virtual lesions on the brain network and cognition in 100 healthy adults (20-65 years old).

Enrollment: 102 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age between 20 and 65 years old
• Native Dutch speaker
• Able to provide written informed consent

Exclusion criteria

• History of diagnosed neurological or psychiatric disease (including traumatic head injury)
• Current and regular use of centrally acting drugs (recreational or prescribed, including analgesics), including the use of alcohol ~8 hours prior to an appointment
• Presence of any contraindications for MRI, MEG, or TMS (including resting motor threshold >75% of maximum stimulator output or no useful motor-evoked potential elicitable)
• Previous rTMS treatment

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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102 participants in 2 patient groups

real rTMS

Experimental group

Description:

verum rTMS to the DLPFC, 1500 1Hz pulses at 120% RMT, 25 minutes total

Treatment:

Device: repetitive transcranial magnetic stimulation (rTMS)

sham rTMS

Sham Comparator group

Description:

sham rTMS to the DLPFC, 1500 1Hz pulses at 120% RMT, 25 minutes total

Treatment:

Device: repetitive transcranial magnetic stimulation (rTMS)