T Regulatory Cells IN LUPUS NEPHRITIS

Assiut University

Status: Not yet enrolling

Conditions: Lupus Nephritis

Treatments: Diagnostic Test: T-reg cells

Study type: Observational

Funder types: Other

Identifiers

NCT06428539

T cells in lupus LN

Details and patient eligibility

About

• To study the role FoxP3-positive T regulatory cells in the pathogenesis of Lupus Nephritis, and determine the factors associated with levels of T regs .
• To compare the functional capacity of T regs in LN and in normal individuals.

Full description

Lupus Nephritis (LN) encompasses a group of glomerulonephrites, that occur in association with systemic lupus erythematosus (SLE). The mainstream theory that it is an immune disease resulting from loss of immune tolerance against body cells. The regulatory T cells (T regs ) are a subpopulation of immune cells that maintain tolerance to self-antigens and suppress autoimmune diseases. The main marker of Tregs is FoxP3 (forkhead box protein 3) positivity. Moreover, It has been suggested that functional capacity of Tregs is also compromised in autoimmune diseases. Studying the role of T regs in LN is a promising field that can help tailor current immune therapy and develop new treatment strategies.

Enrollment: 65 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

adults both genders clinical diagnosis of lupus nephritis

Exclusion criteria

patients diagnosed with other renal pathologies, e.g. diabetic kidney disease

Trial design

65 participants in 3 patient groups

patients with active lupus nephritis

Description:

patients with active lupus nephritis as active urinary sediment, or rising renal chemistry

Treatment:

Diagnostic Test: T-reg cells

patients with lupus nephritis in remission

Description:

Patients who were previously active, but now in remission

Treatment:

Diagnostic Test: T-reg cells

normal individuals

Description:

normal healthy participants

Treatment:

Diagnostic Test: T-reg cells