TACE Combined With Lenvatinib and Sintilimab for Advanced HCC

Second Affiliated Hospital of Guangzhou Medical University

Status and phase

Completed

Phase 2

Conditions

Hepatocellular Carcinoma Non-resectable

Treatments

Drug: TACE combined with lenvatinib and sintilimab

Study type

Interventional

Funder types

Other

Identifiers

NCT04599790

MIIR-04

Details and patient eligibility

About

This study will evaluate the efficacy and safety of transcatheter arterial chemoembolization (TACE) combined with lenvatinib and sintilimab in patients with unresectable advanced hepatocellullar carcinoma (HCC).

Full description

This is a Phase II study to evaluate the efficacy and safety of TACE combined with lenvatinib and sintilimab in patients with advanced HCC.

30 subjects with advanced HCC (Barcelona-Clinic- Liver-Cancer [BCLC] stage C, or China liver cancer staging [CNLC] IIIa and IIIb) will be enrolled in the study.

Lenvatinib 12mg (body weight ≥60kg) or 8mg (body weight <60kg) P.O. qd and sintilimab (200mg I.V. q3w) will be started at 3-7 days after the first TACE. TACE will be repeated if clinically indicated based on the evaluation of follow-up laboratory and imaging examination. Lenvatinib will last until disease progresses, intolerable toxicity, withdrawal of informed consent, loss of follow-up, death, or other circumstances that require termination of treatment, whichever occurs first. Sintilimab will last up to 24 months, or until disease progresses, intolerable toxicity, withdrawal of informed consent, loss of follow-up, death, or other circumstances that require termination of treatment, whichever occurs first. Patients will be allowed to have lenvatinib or sintilimab as a sigle agent and will be still considered on study when the other drug cause intolerable toxicity.

Enrollment

30 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Advanced HCC (BCLC stage C, or CNLC IIIa and IIIb ) with diagnosis confirmed by histology/cytology or clinically
Disease not amenable to curative therapies but amenable to TACE
At least one measurable untreated lesion
No prior systemic therapy for HCC
Child-Pugh score 5-7
Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 at enrollment
Adequate organ and hematologic function
Life expectancy of at least 3 months
For women of childbearing potential and for men: agreement to remain abstinent

Exclusion criteria

Diagnosis of fibrolamellar HCC, sarcomatoid HCC, or mixed cholangiocarcinoma and HCC
Diffuse HCC
Portal vein tumor thrombus (PVTT) involves the main trunk and contralateral branch or upper mesenteric vein
Inferior vena cava tumor thrombus
Metastatic disease that involves major airways or blood vessels
Symptomatic, untreated or progressing central nervous system metastasis
Uncontrolled tumor-related pain
Patients who received prior systemic therapy, immunotherapy, TACE, transcatheter arterial radioembolization (TARE), transcatheter arterial embolization (TAE), hepatic arterial infusion chemotherapy (HAIC) or radiation therapy for HCC
Treatment with systemic immunostimulatory agents
Use of herbal therapies or traditional Chinese medicines with anti-cancer activity within 2 weeks
History of malignancy other than HCC within 5 years prior to screening, except for malignancies with a negligible risk of metastasis or death
Uncontrolled ascites, hydrothorax or pericardial effusion
Prior esophageal and/or gastric varices bleeding within 6 months prior to initiation of study treatment
Prior life-threatening blood loss or grade 3/4 gastrointestinal bleeding requiring blood infusion, endoscopic or surgical intervention within 3 months
Untreated or incompletely treated esophageal and/or gastric varices with bleeding or high-risk for bleeding
History of gastrointestinal (GI) perforation and/or fistula in the past 6 months history of GI obstruction (including incomplete intestinal obstruction requiring parenteral nutrition), extensive bowel resection (partial colectomy or extensive small bowel resection, complicated by chronic diarrhea), Crohn's disease, ulcerative colitis or long-term chronic diarrhea
History of hepatic encephalopathy
History of organ and stem cell transplantation
Long-term daily treatment with a non-steroidal anti-inflammatory drug (NSAID)
Use of immunosuppressive drugs in the past 4 weeks, excluding the routes of topical glucocorticoids or physiological doses of systemic glucocorticoids (ie no more than 10 mg/day of prednisone or equivalent). Temporary use of glucocorticoids for dyspnea symptoms such as asthma and chronic obstructive pulmonary disease is allowed
History of idiopathic pulmonary fibrosis, interstitial pneumonia, drug-induced pneumonitis, or idiopathic pneumonitis, or evidence of active pneumonitis
Active tuberculosis
Active severe infection; use of antibiotics within 2 weeks prior to injection of tislelizumab
Autoimmune disease or immune deficiency
Inadequately controlled hypertension; history of hypertensive crisis or hypertensive encephalopathy
Bleeding diathesis or significant coagulopathy
Serious, non-healing or dehiscing wound, active ulcer, or untreated bone fracture underwent major surgery (craniotomy, thoracotomy or open surgery) within 4 weeks; non-recovery from side effects of these procedure
History of venous thromboembolism in the past 6 months, but implantable IV ports or catheter-derived thrombosis, superficial venous thrombosis, or thrombosis after conventional anticoagulant therapy are excluded
Current or recent use of aspirin or treatment with dipyramidole, ticlopidine, clopidogrel, or cilostazol uncontrolled metabolic disorder, non-malignant organ or systemic disease or secondary carcinomatous reaction, with high medical risk and/or uncertainty of life expectancy evaluation
Other acute or chronic diseases, mental illness, or abnormal laboratory test results that may lead to the following outcomes: increase the risk of participating in study or study drug administration, or interfere with the interpretation of the study results and considered by investigator as "NOT" eligible to participate in this study
Female patients who are pregnancy or breastfeeding