tACS for Sensory Motor Recovery After Stroke

The University of Texas System (UT)

Status: Not yet enrolling

Conditions: Motor Recovery

Treatments: Device: tACS 10Hz; Device: tACS 20Hz; Device: tACS Sham

Study type: Interventional

Funder types: Other

Identifiers

NCT06029062

HSC-MS-22-0046 (Experiment 1)

Details and patient eligibility

About

The overall goal is to investigate the effectiveness of a novel intervention - transcranial alternating current stimulation (tACS) for motor recovery in stroke survivors.

Enrollment: 14 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion/exclusion criteria for stroke subjects

Inclusion criteria:

1. Age between 18~75 years old
2. ≥ 6 months post stroke, medically stable;
3. Unilateral, single stroke (no restriction on type (ischemic or hemorrhagic) or volume (large or small) of stroke);
4. Visible finger flexor activation/movement
5. The ability to give consent

Exclusion criteria:

1. Patients with visual deficit/neglect; hearing or cognitive impairment;
2. Patients that are currently adjusting tone alternating medications (e.g., baclofen), or
3. Patients received botulinum toxin injection to the arm/fingers <4 months, or phenol injections <2 years;
4. Patients with pacemaker, metal implants or supplemental oxygen;
5. Patients who have musculoskeletal disorders, including pain in the affected side
6. Women who are pregnant.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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14 participants in 3 patient groups

tACS Sham, tACS 10Hz, tACS 20Hz

Experimental group

Description:

tACS Sham is a temporary non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for up to 30 second, it is not designed to entrain neuronal activity into any external regulatory frequency patterns. tACS 10Hz is a 10Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp or 20 or 40 minutes to entrain neuronal activity into 10Hz frequency patterns. tACS 20Hz is a 20Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for 20 or 40 minutes to entrain neuronal activity into 20Hz frequency patterns.

Treatment:

Device: tACS Sham

Device: tACS 20Hz

Device: tACS 10Hz

HD-tACS 20Hz, HD-tACS 10Hz, HD-tACS Sham

Experimental group

Description:

tACS Sham is a temporary non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for up to 30 second, it is not designed to entrain neuronal activity into any external regulatory frequency patterns. tACS 10Hz is a 10Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp or 20 or 40 minutes to entrain neuronal activity into 10Hz frequency patterns. tACS 20Hz is a 20Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for 20 or 40 minutes to entrain neuronal activity into 20Hz frequency patterns.

Treatment:

Device: tACS Sham

Device: tACS 20Hz

Device: tACS 10Hz

HD-tACS 10Hz, HD-tACS 20Hz, HD-tACS Sham

Experimental group

Description:

tACS Sham is a temporary non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for up to 30 second, it is not designed to entrain neuronal activity into any external regulatory frequency patterns. tACS 10Hz is a 10Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp or 20 or 40 minutes to entrain neuronal activity into 10Hz frequency patterns. tACS 20Hz is a 20Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for 20 or 40 minutes to entrain neuronal activity into 20Hz frequency patterns.

Treatment:

Device: tACS Sham

Device: tACS 20Hz

Device: tACS 10Hz