tACS Treatment for Cognitive Impairments in Methamphetamine Addicts

Beijing HuiLongGuan Hospital

Status: Completed

Conditions: Methamphetamine Abuse

Treatments: Device: Theta treatment group; Device: Sham control group

Study type: Interventional

Funder types: Other

Identifiers

NCT06292156

CASPsy7

Details and patient eligibility

About

1. To evaluate the cognitive function of methamphetamine Patients.
2. Investigate the pathological mechanism of methamphetamine patients from the aspects of EEG and biology;
3. The investigators investigated the effects of transcranial alternating current stimulation (tACS) on cognitive impairments in methamphetamine patients

Enrollment: 68 patients

Sex: Male

Ages: 18 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Clinical diagnosis diagnosis of methamphetamine use disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5)
• None of participants had mixed use of other drugs
• None of participants had physical disability
• None of participants had acute physical or mental illness, hallucinations, acute withdrawal symptoms
• None of participants were receiving any medical treatment

Exclusion criteria

• Intracranial hypertension
• Cranial defects
• Tumors
• Serious physical illnesses (e.g., cardiovascular, liver, kidney, gastrointestinal disorders)
• Infectious diseases
• Immune system disorders

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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68 participants in 2 patient groups

Theta treatment group

Experimental group

Description:

In active tACS, the target 'active' electrode was placed over the MFC and the second 'return' electrode was placed over the medial parietal cortex. 6 Hz stimulation was used and a alternating current of 2mA was applied for 30min each day(Monday-Friday) for 3 consecutive weeks.

Treatment:

Device: Theta treatment group

Sham control group

Sham Comparator group

Description:

In sham group, Sham stimulation lasted 30 s (15 s of ramp- up and 15 of ramp-down) .

Treatment:

Device: Sham control group