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A clinical study to assess the efficacy and safety of oral tafenoquine compared to placebo in patients with mild to moderate COVID 19 disease.
Full description
The TQ 2020_06 study is a double-blind placebo-controlled, Phase 2 clinical trial that plans to enroll approximately 275 patients with mild to moderate infection with COVID-19. Patients will undergo a brief screening period before being randomized to receive either self-administer 200 mg tafenoquine or matching placebo for 10 days. Following the treatment period, patients will have a follow up visit at study Day 28 (28 days after the first dose of study medication). The study's primary efficacy endpoint is proportion of patients with clinical recovery from COVID-19 symptoms on Day 14 in patients with mild to moderate COVID-19 disease compared with placebo.
Enrollment
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Volunteers
Inclusion criteria
Male or female, aged ≥18 years of age;
Laboratory confirmed infection with COVID-19 virus by an FDA-authorized SARS-Cov-2 RT-PCR;
Able and willing to give written informed consent.
Willing to keep an electronic diary from Study Day 1 to Study Day 13 (± 1 day) and Study Day 15 (± 1 day) to Study Day 28 (± 1 day)
Willing to have daily phone or videoconferences with study team personnel from Study Day 1 to Day 13 (± 1 day) and Day 28
At least one of the following clinical symptoms of COVID-19 infection within the 4 days prior to and inclusive of the day of screening:
Must agree not to enroll in another study of an investigational agent prior to completion of Day 28 of the study.
Able to take ARAKODA or KODATEF according to Prescribing Information
Have been symptomatic no longer than 7 days when the first dose of study medication is administered.
If female, agree to use an acceptable method of birth control from the time of consent through 56 days after the last dose of study drug.
Exclusion criteria
Have one of the contraindications for ARAKODA or KODATEF in the prescribing information (section 16.1) including:
Evidence of severe or critical illness, defined by at least one of the following:
i. Endotracheal intubation and mechanical ventilation, oxygen delivered by high flow nasal cannula (heated, humidified, oxygen delivered via reinforced nasal cannula at flow rates > 20 L/min with fraction of delivered oxygen ≥ 0.5), noninvasive positive pressure ventilation, extracorporeal membrane oxygenation (ECMO), or clinical diagnosis of respiratory failure (i.e., clinical need for one of the preceding therapies, but preceding therapies not able to be administered in setting of resource limitation) ii. Shock (defined by systolic blood pressure < 90 mmHg, or diastolic blood pressure <60 mmHg or requiring vasopressors) iii. Multi-organ dysfunction/failure
Any other clinically significant acute illness unrelated to COVID-19 within seven days prior to first study drug administration
Receipt of any experimental treatment for COVID-19 (off-label, compassionate use, or study-related) within the 30 days prior to the time of the screening evaluation
Any excluded concomitant medication as described in the ARAKODA package insert [Section 16.1]. Receipt of a COVID-19 vaccine is not exclusionary.
Any COVID-19 symptoms which, in the opinion of the investigator, is suggestive of possible requirement to hospitalize within 48 hours of enrollment
Positive pregnancy test
Have been symptomatic for more than seven days when the first dose would be administered
Primary purpose
Allocation
Interventional model
Masking
86 participants in 2 patient groups, including a placebo group
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Data sourced from clinicaltrials.gov
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