Tai Ji Quan and Cognitive Function in Older Adults With Mild Cognitive Impairment

Oregon Research Institute

Status: Active, not recruiting

Conditions: Mild Cognitive Impairment

Treatments: Behavioral: The Go for Exercise & Healthy Aging Project

Study type: Interventional

Funder types: Other

Identifiers

NCT04070703

AG059546

Details and patient eligibility

About

To determine the efficacy of a cognitively enhanced exercise intervention - Tai Ji Quan: Moving to Maintain Brain Health in improving global cognitive function and dual-task ability in older adults with mild cognitive impairment.

Full description

The primary aim of the study is to determine the efficacy of a cognitively enhanced exercise intervention - Tai Ji Quan: Moving to Maintain Brain Health, relative to a standard Tai Ji Quan intervention and an exercise stretching control, in improving global cognitive function and dual-task ability among community-dwelling older adults with amnestic mild cognitive impairment.

Enrollment: 318 patients

Sex: All

Ages: 65 to 95 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• complaint of memory loss
• clinical dementia rating (CDR) scale score ≤0.5
• having normal general cognitive function screened, with MMSE ≥24
• capable of exercising safely, as determined by a healthcare provider
• willingness to be randomly assigned to an intervention condition and complete the 24-week intervention and 6-month follow-up

Exclusion criteria

• having medical conditions likely to compromise survival, such as metastatic cancer, or render a participant unable to engage in physical activity, such as severe cardiac failure
• participating in any type of Tai Ji Quan or daily and/or structured vigorous physical activity (i.e., brisk walking for exercise 30 minutes or longer at a time, or engaging in muscle-strengthening activities, e.g., weight lifting on 3 or more days per week 3 months prior to the study)

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

318 participants in 3 patient groups

Cognitively enhanced Tai Ji Quan

Experimental group

Description:

Participants in this arm will exercise a series of Tai Ji Quan-based movements with configurations that are specifically designed for older adults to improve cognitive function, dual-task ability, strength/balance, and mobility.

Treatment:

Behavioral: The Go for Exercise & Healthy Aging Project

Standard Tai Ji Quan

Active Comparator group

Description:

Serving as an active comparison arm, participants in this intervention will exercise a series of Tai Ji Quan-based movements that are specifically designed for older adults to improve strength/balance, cognitive function, and mobility.

Treatment:

Behavioral: The Go for Exercise & Healthy Aging Project

Stretching

Sham Comparator group

Description:

Serving as a control arm, participants in this intervention will engage in a series of light exercise activities consisting of breathing, stretching, and body relaxation.

Treatment:

Behavioral: The Go for Exercise & Healthy Aging Project