Tailored Internet-delivered Cognitive Behaviour Therapy for Symptoms of Depression and Comorbid Problems (TAYLOR1)

Linköping University (LiU)

Status: Completed

Conditions: Depression; Anxiety Disorders

Treatments: Behavioral: Online discussion group; Behavioral: Tailored Internet-delivered CBT; Behavioral: Non-tailored Internet-delivered CBT

Study type: Interventional

Funder types: Other

Identifiers

NCT01181583

GA-VR-DEP2009-1

Details and patient eligibility

About

The overall aim of this study is to develop and test a tailored Internet-delivered psychological treatment for patients with mild to moderate major depression and comorbid anxiety symptoms and compare its efficacy to a non-tailored treatment and to an active control group.

Full description

Internet-delivered cognitive behaviour therapy (CBT) has emerged as a promising way to administer evidence-based psychological treatments. Mild to moderate major depression has previously been found to treatable via the Internet, with the provision that minimal therapist guidance is given. However, previous research has not taken the issue of comorbidity into account. It is well known that major depression often is accompanied by anxiety and in addition the symptom profile in major depression may differ substantially. The idea behind the proposed research is to tailor the Internet intervention according to the symptom profile. By used a large set of treatment modules (text-based) we aim to diagnose and then prescribe modules. In a randomized trial we want to compare this procedure (e.g., tailored CBT) with the standard Internet-delivered CBT. We will also include a control group in the form of a supervised online discussion group who will later receive CBT.

Enrollment: 121 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinical diagnosis of Major Depressive Disorder
• 15 or more on MADRS-S

Exclusion criteria

• Severe depression (more than 35 on MADRS-S or based on interview)
• Severe psychiatric condition (e.g. psychosis or bipolar disorder)
• Changed medication during the last three months

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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121 participants in 3 patient groups

Tailored Internet-delivered CBT

Experimental group

Treatment:

Behavioral: Tailored Internet-delivered CBT

Non-tailored Internet-delivered CBT

Experimental group

Treatment:

Behavioral: Non-tailored Internet-delivered CBT

Online discussion group

Active Comparator group

Treatment:

Behavioral: Online discussion group