Tailored Versus Traditional Resistance Exercise

Universitaire Ziekenhuizen KU Leuven

Status: Completed

Conditions: Exercise Training

Treatments: Other: 12-week progressive power-oriented resistance exercise program

Study type: Interventional

Funder types: Other

Identifiers

NCT06449716

S68434

Details and patient eligibility

About

Preserving functional ability is crucial for healthy aging. Unfortunately, age-related decreases in muscle power often lead to declines in functional ability. As power is the product of force and velocity, decreases in power can originate from changes in muscle force, contraction velocity, or both, varying between individuals. The primary method to prevent functional disability is power-based resistance training. Although training interventions are effective for most older adults, they do not induce substantial improvements in a subset of the population. These inconsistent outcomes may arise from neglecting the observed differences in the force-velocity (F-v) profiles between individuals. Therefore, this study provides a novel approach to resistance exercise, in which exercise dose is tailored according to the individual's F-v profile. The effectiveness of the tailored method will be assessed in a randomized control trial, comparing the effects of an individualized and a non-individualized 12-week training intervention on muscle power parameters and functional ability.

Enrollment: 80 patients

Sex: All

Ages: 65 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Community-dwelling adults
• 65-80 years old

Exclusion criteria

• Systematic engagement in resistance exercise during the past year
• Unstable cardiovascular disease, neuromuscular disease, acute infection or fever
• Recent surgery
• Lower-extremity injuries
• Low levels of functional ability (i.e., SPPB score ≤ 9)
• Cognitive malfunctioning (i.e., Mini-Mental State Examination < 24)

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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80 participants in 2 patient groups

Individualized resistance exercise program

Experimental group

Description:

Individualized exercise dose. Individuals with a velocity deficit only perform low-load exercises. Individuals with a force deficit only perform high-load exercises.

Treatment:

Other: 12-week progressive power-oriented resistance exercise program

Non-individualized resistance exercise program

Active Comparator group

Description:

Non-individualized exercise dose. All individuals perform a combination of low-load and high-load resistance exercises, regardless of their deficit.

Treatment:

Other: 12-week progressive power-oriented resistance exercise program