Taiwan Cohort - Chronic ThromboEmbolic Pulmonary Hypertension Registry

National Taiwan University

Status: Unknown

Conditions: The Geodemographics of CTEPH in Taiwan

Study type: Observational

Funder types: Other

Identifiers

NCT03667391

201709016RIPC

Details and patient eligibility

About

The diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) is difficult for numerous reasons and is related with a poor prognosis. In Taiwan, the incidence of CTEPH and its clinical features are unknown. This study aims at evaluating the prevalence, clinical characteristics, and management of CTEPH in a Taiwanese cohort.

Primary objective:

• To investigate the geodemographics of CTEPH in Taiwan

Secondary objectives:

• To characterize the demographics and clinical presentation of patients with CTEPH
• To describe the real-world management and treatment outcome of patients with CTEPH
• To identify the risk factors of CTEPH
• To assess the relationship between risk factors/patients' characteristics and clinical outcomes for CTEPH
• To evaluate the prognosis of CTEPH in Taiwan using survival assessment

Enrollment: 200 estimated patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Right heart catheterization (RHC) results that are in line with both of the following haemodynamic levels:

   Mean pulmonary arterial pressure (mPAP) ≥ 25 mmHg at rest AND Pulmonary arterial wedge pressure (PAWP) ≤ 15 mmHg

2. Confirmation of CTEPH diagnosis by one of the following as recommended by standard guidelines:

   At least 1 (segmental) perfusion defect(s) in ventilation-perfusion (V/Q) / perfusion scan OR Pulmonary artery obstruction seen by multidetector computed tomography (MDCT) angiography or conventional pulmonary cineangiography.

3. Presence of pulmonary hypertension or evidence of pulmonary thromboembolism after at least 3 months of anticoagulation treatment.

Exclusion criteria

• not written informed consent
• not meet inclusion criteria