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Tandem Occlusion After Emergent Stenting in Acute Ischemic Stroke (TOESIS)

C

Can Tho Stroke International Services Hospital

Status

Enrolling

Conditions

Ischemic Stroke, Acute
Acute Stroke

Treatments

Procedure: Emergent Stenting

Study type

Interventional

Funder types

Other

Identifiers

NCT06120218
TOESIS Study

Details and patient eligibility

About

In acute ischemic stroke due to tandem occlusion, the emergent stenting has recently become an endovascular treatment option combining with mechanical thrombectomy to achieve recanalization. However, the data on the beneficial endovascular management of tandem occlusion in two circulations is still limited. The purpose of our study was to compare the improvement of clinical outcome between two circulations after emergent stenting at 3 months.

Full description

The posterior circulation (about 20 - 25%) is less frequent than the anterior one in the acute ischemic stroke, but high mortality and morbidity in the acute vertebrobasilar thrombosis even successful recanalization are revealed. Besides, tandem occlusion is one of the complex lesions in large vessel occlusions relating to the poor outcome, particularly in the posterior circulation. Recent studies have suggested that emergent stenting could be used as an additional treatment to achieve permanent recanalization together with mechanical thrombectomy in the intracranial segments. Permanent recanalization is one of the most important factors that impact patient outcomes after acute ischemic stroke. However, although there are various approaches for this lesion, the comparision of the effectiveness in the two circulations remains unclear. Thus, the aims of our study were to compare baseline characteristics and clinical outcome of tandem occlusions between anterior and posterior circulation after emergent stenting in extracranial arteries.

Enrollment

110 estimated patients

Sex

All

Ages

19 to 100 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Age > 18 years old
  • Premorbid mRS < 2
  • NIHSS > 5
  • ASPECTS ≥ 5 or pc-ASPECTS ≥ 5

Exclusion criteria

  • Onset to treatment time > 24 hours
  • Loss to follow up after discharge

Trial design

Primary purpose

Treatment

Allocation

Non-Randomized

Interventional model

Single Group Assignment

Masking

None (Open label)

110 participants in 2 patient groups

Emergent Stenting in Anterior circulation
Experimental group
Description:
Emergent Carotid Stenting in acute ischemic stroke caused by tandem occlusions
Treatment:
Procedure: Emergent Stenting
Emergent Stenting in Posterior circulation
Experimental group
Description:
Emergent Extracranial Vertebral Stenting in acute ischemic stroke caused by tandem occlusions
Treatment:
Procedure: Emergent Stenting

Trial contacts and locations

1

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Central trial contact

Can Tho Stroke International Services Hospital; Cuong Tran Chi, Doctor

Data sourced from clinicaltrials.gov

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