TAP Block , Intrathecal Morphine Or Their Combination For Post Operative Analgesia Following TAH

Minia University

Status and phase: Active, not recruiting; Phase 1

Conditions: Post-operative Pain Management

Treatments: Drug: spinal anesthesia; Procedure: TAP Block; Drug: Intrathecal morphine injection

Study type: Interventional

Funder types: Other

Identifiers

NCT06882369

TAP vs. morphine vs. both

Details and patient eligibility

About

This randomized controlled clinical trial designed to evaluate the efficacy of transversus abdominis plane (TAP) block, intrathecal morphine, or their combination in postoperative pain relief, as assessed by time to first analgesic request, pain scores, total postoperative analgesic consumption, time of ambulation, complications and hemodynamics following total abdominal hysterectomy.

Enrollment: 75 patients

Sex: Female

Ages: 30 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Female patients aged 30 to 70 years.
• Elective total abdominal hysterectomy.
• ASA physical status I or II.
• Willingness to provide informed consent.

Exclusion criteria

• Refusal of the block.
• Allergy to study medications.
• Preexisting coagulation disorders.
• Local infection at the site of needle insertion.
• Uncontrolled respiratory or cardiac disorders.
• Impaired kidney or liver function.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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75 participants in 3 patient groups

TAP block

Active Comparator group

Description:

Bilateral ultrasound-guided TAP block with 20 mL of 0.25% plain bupivacaine on each side of the abdomen at the end of surgery.

Treatment:

Procedure: TAP Block

Drug: spinal anesthesia

Intrathecal Morphine

Active Comparator group

Description:

Intrathecal injection of 100 µg morphine plus 20 mg hyperbaric bupivacaine (in spinal anesthesia).

Treatment:

Drug: Intrathecal morphine injection

Drug: spinal anesthesia

Combined

Active Comparator group

Description:

Intrathecal injection of 50 µg morphine plus 20 mg hyperbaric bupivacaine combined with bilateral ultrasound-guided TAP block using 20 mL of 0.25% plain bupivacaine on each side of the abdomen at the end of surgery.

Treatment:

Drug: Intrathecal morphine injection

Procedure: TAP Block

Drug: spinal anesthesia