TAP Block With Magnesium Sulfate Added to Local Anesthetic in Abdominal Hysterectomy

Assiut University

Status and phase: Unknown; Phase 3; Phase 2

Conditions: Postoperative Pain

Treatments: Drug: Bupivacaine; Drug: Magnesium Sulfate

Study type: Interventional

Funder types: Other

Identifiers

NCT02930707

177

Details and patient eligibility

About

Major abdominal surgeries are associated with severe abdominal pain, which can affect respiratory and cardiac functions, if insufficiently managed. This increases the incidence of post-operative morbidity.

The objective of this study was to detect the efficacy and safety of magnesium sulphate as an adjuvant to the analgesia offered by local anesthetic in ultrasound guided TAP block in patients undergoing total abdominal hysterectomy.

Enrollment: 60 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• weight: 50- 85 kg.
• ASA score: I-III
• scheduled for total abdominal hysterectomy

Exclusion criteria

• history of relevant drug allergy.
• coagulation disorders.
• opioid dependence.
• sepsis.
• psychiatric illnesses that would interfere with perception and assessment of pain.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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60 participants in 2 patient groups, including a placebo group

Magnesium group

Active Comparator group

Description:

patients received ultrasound guided TAP block with 20 mL of 0.25% bupivacaine plus 2 mL magnesium sulphate 10% (200 mg), on each side of the abdominal wall.

Treatment:

Drug: Magnesium Sulfate

control group

Placebo Comparator group

Description:

patients received ultrasound guided TAP block with 20 mL of 0.25% bupivacaine on each side of the abdominal wall.

Treatment:

Drug: Bupivacaine