TAP Blocks vs. IV Lidocaine for Kidney Transplants

Benaroya Research Institute

Status and phase: Unknown; Phase 3; Phase 2

Conditions: Postoperative Pain

Treatments: Drug: Intravenous Lidocaine; Procedure: Transversus Abdominis Plane Block

Study type: Interventional

Funder types: Other

Identifiers

NCT03843879

IRB18-109

Details and patient eligibility

About

This study will compare continuous intravenous lidocaine against single-injection transversus abdominis plane (TAP) block as a modality for postoperative analgesia in kidney transplant surgery.

Full description

This study is a non-inferiority trial designed to assess the analgesic efficacy of an intravenous (IV) lidocaine infusion against single-injection transversus abdominis plane (TAP) block in patients undergoing kidney transplant surgery. The investigators propose a study of 124 subjects randomized into two groups. The control group will receive a TAP block. The study group will receive a continuous IV lidocaine infusion. The investigators hypothesize that there will be no statistically significant difference in postoperative opioid consumption between the two groups in the first 24 hours.

Enrollment: 124 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Kidney transplant recipient
• >18 years old
• Consent to participate

Exclusion criteria

• <18 years old
• Refusal to participate
• Chronic opioid use
• Seizure disorder
• Allergy to local anesthestics
• Severe hepatic disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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124 participants in 2 patient groups

TAP Block

Active Comparator group

Description:

Single-injection transversus abdominis plane block

Treatment:

Procedure: Transversus Abdominis Plane Block

IV Lidocaine

Active Comparator group

Description:

Continuous intravenous lidocaine infusion

Treatment:

Drug: Intravenous Lidocaine