Tapentadol Versus Oxycodone - a Mechanism-based Treatment Approach in Neuropathic Pain

University Hospital Schleswig-Holstein (UKSH)

Status and phase: Terminated; Phase 4

Conditions: Peripheral Neuropathy

Treatments: Drug: tapentadol, oxycodone

Study type: Interventional

Funder types: Other

Identifiers

NCT01458015

TapOxy01

Details and patient eligibility

About

The purpose of this study is to elucidate whether the additional mechanism of analgesia, i.e. reuptake inhibition of norepinephrine, of tapentadol leads to a change in different pain signs and symptoms in comparison to oxycodone.

Enrollment: 3 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• thermal or mechanical hyperalgesia
• chronic neuropathic pain (NRS => 6)

Exclusion criteria

• non-specific

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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3 participants in 2 patient groups

oxycodone

Active Comparator group

Treatment:

Drug: tapentadol, oxycodone

tapentadol

Active Comparator group

Treatment:

Drug: tapentadol, oxycodone