Target ADHD Executive Working Memory Study
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Treatments
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About
This study will assess whether or not a novel executive working memory training intervention for Attention-Deficit/Hyperactivity Disorder can engage frontoparietal brain network treatment targets and behavioral performance.
Full description
This proposal seeks support for a 2-year milestone-driven R61 initial test of target engagement in n=62 ADHD diagnosed adolescents randomized to a 'sham training' placebo or to train 4 times each week using 4 different EWM exercises that have been combined into the format of a typical cognitive training intervention. Exercise difficulty levels in the active intervention will increase across 5 weeks to continually challenge EWM ability. EWM training will use a novel, remotely-supervised 'at home' computerized training approach. If R61 EWM training target engagement milestones are met, a 3-year R33 phase will begin. The R33 will replicate target engagement in another randomized placebo-controlled trial of n=90 new ADHD adolescents and attempt to establish a convincing link between the hypothesized targets and ADHD symptom expression. It also will characterize ADHD brain activity or EWM ability changes relative to typical levels seen in an n=40 non-ADHD control group.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Diagnosis of ADHD
- English speaking
- Right-handed
- >5th grade reading level
- >80 IQ level
Exclusion criteria
- Braces, metal or implant devices
- Brain abnormality, neurological disorder
- TBI or loss of consciousness>30 minutes
- Diagnosis of Psychosis, Bipolar Disorder, ASD, PTSD, OCD, SUD, Tourette's Disorder
Trial design
Primary purpose
Allocation
Interventional model
Masking
62 participants in 2 patient groups, including a placebo group
Trial contacts and locations
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Central trial contact
Jacey C Anderson, BA; Karen L Kesten, MS
Data sourced from clinicaltrials.gov
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