Target Mitochondrial Fitness, Chronobiology and Metabolism (PI19/00507)

Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud

Status: Active, not recruiting

Conditions: Healthy Subjects

Treatments: Other: Aerobic or anaerobic exercise

Study type: Interventional

Funder types: Other

Identifiers

NCT05600192

PI19/00507

Details and patient eligibility

About

Exercise could be an element that affects the biochemical, metabolic and microbiome parameters of organisms. Thus, to identify and validate the effects of aerobic and anaerobic exercises at different times of the day (morning or afternoon) on mitochondrial fitness and whether this changes could have a relation with metabolism and cardiovascular parameters and microbiome is of great interest for its applicability in biomedicine.

As specific objectives of this project will study:

1. • To study the direct effect of aerobic and anaerobic exercise at different time points in the day on mitochondria fitness (short study: basal, at the end of the exercise and 2 h after exercise).
2. • To study mitochondria fitness under morning or afternoon aerobic and anaerobic exercise (prospective study: basal, 4, 8 and 12 weeks of the study).
3. • To identify and validate modulators and target proteins of mitochondria fitness affected by exercise (miRNA omic and proteomic analysis of mitochondria from the different groups of the study at basal and 12 weeks of the study).
4. • To study the relationship of the mitochondrial response (Objectives 1 and 2) to the different combination of exercises and chronobiology with anthropometric-clinical, carbohydrate and lipid metabolic and cardiovascular changes.
5. • To check the effect of morning or afternoon aerobic and anaerobic exercise on gut microbiota and its relation to mitochondria fitness, clinical and metabolic parameters (basal, 4, 8 and 12 weeks of the study).

Enrollment: 100 patients

Sex: All

Ages: 20 to 55 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 20-
• IMC <30 kg/m2
• Informed consent

Exclusion criteria

• Smoker
• Previous physical exercise of more than 20 minutes / 2 times a week

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

100 participants in 1 patient group

Exercise arm

Experimental group

Description:

Subjects perfom aerobic or anaerobic exercise in the morning or in the afternoon

Treatment:

Other: Aerobic or anaerobic exercise