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Target Organ Damage in Patients With Repaired Coarctation of Aorta and Exercise Induced Hypertension

U

University Medical Centre Ljubljana

Status

Invitation-only

Conditions

Coarctation of the Aorta

Study type

Observational

Funder types

Other

Identifiers

NCT07134621
0120-135/2023/6

Details and patient eligibility

About

The goal of this observational study is to obtain data on the effect of exercise induced hypertension on target organs in adult patients with repaired coarctation of the aorta. The main questions it aims to answer are:

  • patients with exercise induced hypertension have signs of hypertensive heart disease?
  • patients with exercise induced hypertension have increased arterial stiffness?
  • patients with exercise induced hypertension have signs of hypertensive renal damage? Participants will be invited for an outpatient appointment during which medical history and physical investigation will be performed. They will undergo cardiopulmonary exercise testing during which blood pressure will be measured regularly. Transthoracic echocardiography will also be performed as well as assessment of arterial stiffness by measuring pulse wave velocity. Renal function will be assessed by blood and urine analysis.

Enrollment

50 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • adult patients aged 18 years and older
  • history of coarctation of aorta repair

Exclusion criteria

  • haemodynamically significant recoarctation
  • arterial hypertension at rest
  • antihypertensive therapy
  • associated haemodynamically significant valvular heart disease
  • associated complex congenital heart disease
  • advanced heart failure
  • symptomatic arrhythmias
  • cognitive or physical limitations to perform exercise stress testing

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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